PB2540 a Novel fluorescent cannabinoid receptor (CB1) antagonist

Tail Artery Adventitia. Red/Orange showsPB2540 binding to Vascular nerves.

Tail Artery Adventitia. CB1 rich cell (red/orange) beside two alpha1-adrenoceptor rich (green) cells

Tail Artery Media. Patch of CB1 rich smooth muscle cells

Tail Artery Media. Cross section of the wall. Smooth muscle cells in profile with adventitial cells above (cobtaining CB1 receptors)

Mesenteric artery smooth muscle cells. Co-localisation of CB1 and alpha1-ARs

CB1 receptors on perivascular fat (left) and nerves (right)

 

3D views of CB1 binding (orange) on the perivascular fat shown above (right)